Synthesis of Vectorized Nanoparticles Based on a Copolymer of N-Vinyl-2-Pyrrolidone with Allyl Glycidyl Ether and a Carbohydrate Vector

A method was developed for the conjugation of aminopropyl spacer-bearing carbohydrates with epoxy groups on crown nanoparticles consisting a copolymer N-vinyl-2-pyrrolidone and allyl glycidyl ether in basic buffer, opening prospects design vectorized nanocomposite drug forms. conjugate above trisaccharide A, synthetic blood group antigen, synthesized. Meglumine used to bind any unreacted epoxide fragment. One- two-dimensional NMR spectroscopy showed quantitative ring as result carbohydrate immobilization. By integrating characteristic signals 1H spectrum, we determined molar ratio immobilized vector meglumine, well composition number-average molecular weight carrier copolymer. The results obtained point interesting possibilities further study polymer–carbohydrate ligand system platform development several carriers theranostics based them.